亚胺培南西司他丁钠治疗急诊重症感染的价值

The value of imipenem and cilastatin sodium in the treatment of severe infection in emergency department

目的研究亚胺培南西司他丁钠治疗急诊重症感染的价值。方法50例重症感染患者,随机分为对照组与研究组,每组25例。对照组采用普通抗感染治疗,研究组采用亚胺培南西司他丁钠治疗。比较两组患者治疗效果、细菌消除率、生活质量评分、药物不良反应发生情况。结果研究组患者的总有效率92.00%(23/25)高于对照组的68.00%(17/25),差异有统计学意义(P<0.05)。研究组患者的细菌消除率84.00%高于对照组的56.00%,差异有统计学意义(P<0.05)。治疗后,研究组患者的肌体疼痛评分为(88.65±5.79)分,健康状况评分为(86.24±5.16)分,活力状态评分(84.98±6.44)分,躯体功能评分为(84.28±4.89)分,均高于对照组的(72.15±2.11)、(74.56±2.49)、(73.58±2.66)、(74.25±2.16)分,差异有统计学意义(P<0.05)。两组患者药物不良反应发生率对比差异无统计学意义(P>0.05)。结论亚胺培南西司他丁钠在治疗急诊重症感染方面具有显著的应用价值,值得推崇与使用。

Objective To study the value of imipenem and cilastatin sodium in the treatment of severe infection in emergency department.Methods A total of 50 patients with severe infection were randomly divided into control group and research group,with 25 cases in each group.The control group received ordinary anti-infection treatment,and the research group received imipenem and cilastatin sodium for treatment.The therapeutic effect,bacterial elimination probability,quality of life score,and occurrence of adverse drug reactions were compared between the two groups.Results The total effective rate of the research group was 92.00%(23/25),which was higher than 68.00%(17/25)of the control group,and the difference was statistically significant(P<0.05).The bacterial elimination probability 84.00%of the research group was higher than 56.00%of the control group,and the difference was statistically significant(P<0.05).After treatment,the body pain score(88.65±5.79)points,health status score(86.24±5.16)points,vitality status score(84.98±6.44)points and physical function score(84.28±4.89)points of the research group were higher than(72.15±2.11),(74.56±2.49),(73.58±2.66)and(74.25±2.16)points of the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in incidence of adverse drug reactions between the two groups(P>0.05).Conclusion Imipenem and cilastatin sodium has significant practical value in the treatment of severe infection in emergency department,and it is worthy of promotion and application.