结节性多动脉炎的诊断进展

Progress in diagnosis of polyarteritis nodosa

结节性多动脉炎(polyarteritis nodosa,PAN)是一种罕见的原发性的坏死性血管炎(necrotizing vasculitis),患者通常为抗中性粒细胞胞浆抗体阴性,影响中等大小的肌动脉,尤其是心脏、肾脏等的血管组织。PAN临床表现、病程及治疗方法均不相同,几乎可侵犯每个器官,但较少累及肺部。PAN可以是特发性的,亦可是继发于其他原因,典型的为病毒感染。本文就目前PAN的诊断进展作一综述,旨在对新的治疗方案的开发及相关病因学研究提供一定参考。

Polyarteritis nodosa(PAN) is a rare primary necrotizing systemic vasculitis.Patients with PAN are usually negative for antineutrophil cytoplasmic antibody,which affects medium-sized muscle arteries,especially the heart and kidney.The clinical manifestations,course of disease and treatment of PAN are different.PAN can invade almost every organ,but rarely affect the lung.PAN can be idiopathic or secondary to other causes,typically viral infection.In this paper,the progress of diagnosis of PAN was reviewed in order to provide a reference for the development of new treatment and related etiology.