3-巯基丙酸制备的研究进展

Development of 3-mercaptopropionicacid Preparation

3-巯基丙酸是生产医药芬那露的中间体,也可用于制备抗氧剂、硬化剂、交联剂、生化试剂、树脂添加剂和催化剂,也是生产PVC热稳定剂酯基锡的原料,有很广阔的市场前景。综述了近几年来3-巯基丙酸合成的研究进展情况,总结文献及课题组初步测试结果得出以丙烯酸与硫化氢为原料,以离子交换树脂为催化剂,3-巯基丙酸收率高,是理想的合成路线。

3-mercaptopropionic acid is an intermediate in the production of pharmaceutical fenarol, and can be also used in the preparation of antioxidants, hardeners, cross-linking agents, biochemical reagents, resin additives and catalysts. It is also the raw material for the production of PVC heat stabilizer ester tin. 3-mercaptopropionic acid has a very broad market prospect. In this paper, the research progress in synthesis of 3-mercapto-propionic acid in recent years is reviewed, and the literature and the preliminary test results of our research group are summarized. It is concluded that using acrylic acid and hydrogen sulfide as raw materials and ion exchange resin as catalyst to synthesize 3-mercaptopropionic acid with high yield is an ideal synthesis route.