软骨细胞力学信号转导在骨性关节炎中的作用

Role of Chondrocyte Mechanotransduction in Development of Osteoarthritis

异常力学负荷是骨关节炎发生的主要危险因素,可导致胶原降解、糖胺聚糖丢失和软骨细胞凋亡,引起软骨和软骨下骨破坏。然而,由于对软骨细胞力学传导认识不足,以及各种软骨修复再生手段的效果并不理想,故迫切需要了解软骨细胞力学传导过程以及软骨机械性损伤发生机制,以期望为研究软骨损伤修复和再生提供参考。详细介绍力学信号如何从细胞外经由细胞膜传至细胞内力学感受器,并着重讨论相关力学传导的信号通路在骨性关节炎中的作用。

Abnormal mechanical loading is the main risk factor for the development of osteoarthritis( OA),and it can lead to collagen degradation,glycosaminoglycan loss and chondrocyte apoptosis,as well as damage to articular cartilage and subchondral bone. However, due to the lack of understanding in chondrocytes mechanotransduction pathway and invalid method of cartilage repair and regeneration,there is an urgent need for understanding chondrocytes mechanotransduction pathway and mechanism of cartilage damage induced by mechanical loading. In this review,how chondrocytes sense and transmit mechanical signals from cell membrane to cecullar mechanosensors is introduced in detail,and the role of chondrocytes mechanotransduction in OA development is discussed with emphasis.