清热解毒方联合干扰素治疗宫颈人乳头瘤病毒感染临床研究

Clinical Study on Qingre Jiedu Prescription Combined with Interferon for Cervical HPV Infection

目的:观察清热解毒方联合干扰素治疗宫颈人乳头瘤病毒(HPV)感染的临床疗效。方法:选取75例宫颈HPV感染患者,根据随机数字表法分为干扰素治疗组37例和联合治疗组38例。干扰素治疗组给予重组人干扰素α2b阴道泡腾片治疗,联合治疗组在此基础上加服清热解毒方,2组均连续治疗3个月经周期。比较2组临床疗效、HPV转阴率、炎症因子水平及不良反应。结果:联合治疗组临床疗效优于干扰素治疗组(Z=2.698,P<0.05)。治疗后,联合治疗组HPV转阴率为81.58%,高于干扰素治疗组的67.57%(χ^(2)=5.176,P<0.05)。治疗后,联合治疗组阴道冲洗液中白细胞介素-2 (IL-2)水平及IL-2/白细胞介素-4 (IL-4)值均高于干扰素治疗组(P<0.05),IL-4水平低于干扰素治疗组(P<0.05)。治疗期间,2组均未发生明显不良反应。结论:清热解毒方联合干扰素治疗宫颈HPV感染,可有效促进HPV转阴,纠正阴道局部免疫平衡,且安全性高。

Objective: To observe the clinical effect of Qingre Jiedu prescription combined with interferon on cervical human papillomavirus(HPV) infection. Methods:Seventy-five patients with cervical HPV infection were selected and divided into the interferon group(37 cases) and the combination group(38 cases) according to random number table method. The interferon group was treated with recombinant human interferon α2 b vaginal effervescent tablets,and the combination group was additionally treated with Qingre Jiedu prescription based on the treatment of the interferon group. Both groups were treated for three menstrual cycles. The clinical effect, HPV negative conversion rate, levels of inflammatory cytokine and adverse reactions were compared between the two groups. Results:The clinical effect in the combination group was better than that in the interferon group(Z=2.698,P<0.05). After treatment,the negative HPV conversion rate in the combination group was 81.58%,higher than that of 67.57% in the interferon group(χ^(2)=5.176,P<0.05). After treatment,the levels of interleukin-2(IL-2) and the value of interleukin-2/interleukin-4(IL-4) in vaginal rinse fluid in the combination group were higher than those in the interferon group(P<0.05);the IL-4 level was lower than in the combination group(P<0.05). During treatment, no obvious adverse reactions occurred in both groups. Conclusion: Qingre Jiedu prescription combined with interferon for cervical HPV infection,can effectively promote HPV negative rate,regulate the local vaginal immune balance,and the safety is great.