摘要
目的:观察扶正解毒汤联合甲泼尼龙治疗系统性红斑狼疮的临床疗效。方法:选取74例系统性红斑狼疮患者,按随机数字表法分为研究组和对照组各37例。对照组给予甲泼尼龙治疗,研究组给予扶正解毒汤联合甲泼尼龙治疗。比较2组临床疗效、系统性红斑狼疮疾病活动度量表(SLEDAI)评分、血清干扰素-γ(IFN-γ)含量、骨髓抑制率及不良反应情况。结果:研究组总有效率为97.30%,高于对照组81.08%,差异有统计学意义(P<0.05)。治疗前,2组SLEDAI评分比较,差异无统计学意义(P>0.05)。治疗后4周、8周,2组SLEDAI评分逐渐降低,且研究组SLEDAI评分低于同时间点对照组,差异均有统计学意义(P<0.05)。治疗前,2组血清IFN-γ含量比较,差异无统计学意义(P>0.05)。治疗后4周、8周,2组血清IFN-γ含量逐渐降低,且研究组血清IFN-γ含量低于同时间点对照组,差异均有统计学意义(P<0.05)。治疗后,研究组骨髓抑制率为10.81%,显著低于对照组32.43%,差异有统计学意义(P<0.05)。研究组不良反应发生率为16.22%,显著低于对照组37.84%,差异有统计学意义(P<0.05)。结论:扶正解毒汤联合甲泼尼龙可改善系统性红斑狼疮患者的临床症状及血清IFN-γ含量,降低骨髓抑制率,安全可靠。
Objective: To observe the clinical effect of Fuzheng Jiedu tang combined with methylprednisolone for systemic lupus erythematosus. Methods:A total of 74 cases of patients with systemic lupus erythematosus were selected and divided into the study group and the control group according to random number table method,37 cases in each group.The control group was given methylprednisolone, and the study group was given Fuzheng Jiedu tang combined with methylprednisolone. The clinical effect, scores of Systemic Lupus Erythematosus Disease Activity Index(SLEDAI), the content of interferon-γ(IFN-γ) in serum, the rate of myelosuppression, and the incidence of adverse reactions were compared between the two groups. Results: The total effective rate was 97.30% in the study group, higher than that of81.08% in the control group,the difference being significant(P<0.05). Before treatment,there was no significant difference being found in the comparison of SLEDAI scores between the two groups(P>0.05). After four-week and eight-week treatment,SLEDAI scores in the two groups were gradually decreased,and the score in the study group was lower than that in the control group at the same time point, differences being significant(P<0.05). Before treatment, there was no significant difference being found in the comparison of IFN-γ contents in serum between the two groups(P>0.05). After fourweek and eight-week treatment,IFN-γ contents in serum in the two groups were gradually decreased,and the content in the study group was lower than that in the control group at the same time point,differences being significant(P<0.05). After treatment,the rate of myelosuppression was 10.81% in the study group,which was significantly lower than that of 32.43%in the control group,the difference being significant(P<0.05). The incidence of adverse reactions was 16.22% in the study group, significantly lower than that of 37.84% in the control group, the difference being significant(P<0.05). Conclusion:For patients with systemic lupus erythematosus,the therapy of Fuzheng Jiedu tang combined with methylprednisolone can safely improve their clinical symptoms and IFN-γ content in serum,and reduce the rate of myelosuppression.
作者
张智勇
刘娟云
许瑞
陈金红
ZHANG Zhiyong;LIU Juanyun;XU Rui;CHEN Jinhong
出处
《新中医》
CAS
2021年第13期101-104,共4页
New Chinese Medicine
关键词
系统性红斑狼疮
扶正解毒汤
甲泼尼龙
系统性红斑狼疮疾病活动度量表
干扰素-Γ
骨髓抑制率
Systemic lupus erythematosus
Fuzheng Jiedu tang
Methylprednisolone
Systemic Lupus Erythematosus Disease Activity Index
Interferon-γ
Rate of myelosuppression