小柴胡汤加减联合化疗治疗乳腺癌临床研究

Clinical Study on Modified Xiaochaihu Tang Combined with Chemotherapy for Breast Cancer

目的:观察小柴胡汤加减联合化疗治疗乳腺癌的临床疗效及对血清肿瘤标志物的影响。方法:选取88例乳腺癌患者,根据使用药物的不同分为2组,对照组给予常规化疗,研究组在对照组的基础上加用小柴胡汤加减,2组持续治疗63 d。比较2组临床疗效、血清肿瘤标志物、T细胞亚群及免疫球蛋白水平。结果:研究组总有效率为77.3%,临床受益率为97.8%,均高于对照组的56.8%、79.5%(P<0.05)。与同组治疗前比较,2组治疗后可溶性E-钙粘连蛋白(sEC)、胰岛素样生长因子-1 (IGF-1)、糖类抗原125 (CA125)、糖类抗原153 (CA153)、癌胚抗原(CEA)、CD4^(+)、CD4^(+)/CD8^(+)、免疫球蛋白A (IgA)、免疫球蛋白G (IgG)、免疫球蛋白M (IgM)均降低(P<0.05),CD8^(+)升高(P<0.05),研究组CD3^(+)降低;与对照组治疗后比较,研究组治疗后sEC、IGF-1、CA125、CA153、CEA、CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)、IgA、IgG、IgM均较低(P<0.05),CD8^(+)较高(P<0.05)。结论:小柴胡汤加减联合化疗治疗乳腺癌患者不仅可以提高疗效,还可以改善血清肿瘤标志物。

Objective:To observe the clinical effect of modified Xiaochaihu tang combined with chemotherapy for breast cancer and its effect on serum tumor markers.Methods:A total of 88 cases of patients with breast cancer were selected and divided into two groups according to different drug application.The control group was given routine chemotherapy,and the study group was additionally treated with modified Xiaochaihu tang based on the treatment of the control group.Both groups were treated for 63 days.The clinical effect and the levels of serum tumor markers,T cell subsets and immunoglobulin in the two groups were compared.Results:The total effective rate and clinical benefit rate were 77.3%and 97.8%respectively in the study group,higher than those of 56.8%and 79.5%respectively in the control group(P<0.05).After treatment,the levels of soluble E-cadherin(sEC),insulin-like growth factor-1(IGF-1),carbohydrate antigen 125(CA125),carbohydrate antigen 153(CA153),carcinoembryonic antigen(CEA),CD4^(+),CD4^(+)/CD8^(+),immunoglobulin A(IgA),immunoglobulin G(IgG)and immunoglobulin M(IgM) in the two groups were decreased when compared with those before treatment(P<0.05),and CD8^(+)was increased(P<0.05),CD3^(+)were decreased in the study group(P<0.05).After treatment,the levels of sEC、IGF-1、CA125、CA153、CEA、CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)、IgA、IgG、IgM in the study group were lower than those in the control group(P<0.05);CD8^(+)were higher(P<0.05).Conclusion:The therapy of modified Xiaochaihu tang combined with chemotherapy for patients with breast cancer can enhance the curative effect and improve the serum tumor markers.