细胞周期调节因子Cdh1与肿瘤关系研究进展

Research Progress on the Relationship between Cell Cycle Regulator Cdh1 and Tumor

肿瘤的发生和细胞周期调节异常存在十分密切的联系,Cdh1是细胞周期调节的关键因子之一,主要通过与后期促进复合物APC/C泛素连接酶形成APCCdh1复合物在有丝分裂M晚期和G1早期发挥调节作用,APCCdh1失活也被认为是决定细胞进入细胞周期不可逆的关键事件。越来越多的研究显示,Cdh1除了作为细胞周期正常运行的核心调节因子以外,也是一种重要的肿瘤抑制因子,与BRAF、Src、AKT等多条癌症相关信号通路存在相互作用,其功能缺失与肿瘤的发生、发展、侵袭、转移以及化疗耐药等多个方面关系密切,靶向Cdh1策略已成为当前肿瘤防治研究突破新方向,全文就近年来Cdh1与肿瘤关系的研究进展进行综述。

The occurrence of tumors has close related to abnormal cell cycle regulation. Cdh1 is one of the critical factors in cell cycle regulation and plays an important regulating role in late M and early G1 stages of mitotic period through forming APCCdh1 compounds with APC/C ubiquitin ligase. It is considered that APCCdh1 deactivation is the crucial event determining entering the cell cycle irreversibly. More and more studies showed that Cdh1 is also a critical tumor suppressor,which interplays with multiple cancer related signaling pathways,including mutated BRAF,Src,AKT,etc. The loss of cdh1 function has been verified to be closely associated with tumor occurrence,development,invasion,metastasis,and drug resistance. Currently the strategy targeting Cdh1 has become a new direction for cancer research,and this article reviews the progress on the relationship between Cdh1 and tumors.