姜黄素单独及联合其他药物抗喉癌作用机制研究进展

Mechanism of Curcumin Alone and in Combination with Other Drugs Against Laryngeal Carcinoma:A Review

姜黄是一味传统中药,具有活血行气的功效。姜黄素是从植物姜黄的根茎中提取出的一种多酚类物质,具有抗肿瘤、抗氧化、抗菌和抗炎等多种药理作用。喉癌是一种常见的恶性肿瘤,近年来,其发病率不断上升,且5年生存率不断下降。因喉部所处位置特殊,研究人员正积极探索多样化的治疗方式,以喉部器官保存为主要目标。研究表明,姜黄素对喉癌的发展有抑制作用。姜黄素的药理作用众多,其研究价值大,但目前多数研究局限于体外实验,姜黄素的部分作用机制也尚未明确,姜黄素成为抗喉癌的临床中药制剂之路还很漫长。该文总结了姜黄素的理化性质和从植物中提取的方法,姜黄素在诱导细胞凋亡、抑制细胞增殖、诱导细胞保护性自噬、逆转细胞耐药性、抑制细胞迁移及侵袭和抑制肿瘤血管新生等方面抗喉癌的机制,姜黄素联合白藜芦醇,铂类化疗药物,3-甲基腺嘌呤,紫杉醇类药物和5-氟尿嘧啶等药物抗喉癌的作用机制;姜黄素、喉癌相关的生物信息学分析等方面的内容,以期为相关研究者明确姜黄素抗喉癌作用机制及重要靶点提供参考,为姜黄素的深入研究和应用提供思路。

Curcumae Longae Rhizoma is a traditional Chinese medicine with the efficacy of activating blood and moving Qi. Curcumin,a polyphenolic substance extracted from the rhizome of plant Curcuma longa,possesses multiple pharmacological activities like anti-tumor, anti-oxidation, anti-bacteria, and antiinflammation. Laryngeal carcinoma(LC)is a common malignant tumor,whose incidence in recent years has been on the rise,and the 5-year survival rate has continuously decreased. Considering the specific location of larynx,researchers are actively exploring diverse treatment modalities for laryngeal organ preservation. Many studies have shown that curcumin has an inhibitory effect on the development of LC. By virtue of multiple pharmacological effects,curcumin deserves to be thoroughly explored. However,most of the current research is limited to in vitro exploration,and the partial mechanism of curcumin remains unclear,indicating that there is still a long way to go before curcumin becomes a Chinese medicinal preparation for the clinical treatment of LC.This paper reviewed the physicochemical properties of curcumin and the methods for its extraction from plants,the efficacy of curcumin in inducing cell apoptosis and protective autophagy,reversing cell drug resistance,inhibiting cell proliferation,migration,and invasion and tumor angiogenesis,the action mechanism of curcumin in combination with resveratrol,platinum drugs,3-methyladenine,taxols,and 5-fluorouracil against LC,as well as the bioinformatics analysis concerning curcumin and LC. This paper is expected to provide reference for relevant researchers to clarify the mechanism and important targets of curcumin against LC and promote its clinical application.