摘要
Obstructive sleep apnea(OSA)is a common sleep-disordered breathing disease that often leads to many comorbidities(e.g.,cognitive dysfunction),which adversely affect the quality of life for patients with OSA.Thus far,the underlying mechanisms of this dysfunction remain unclear.Many studies have focused on OSA-related characteristics,including intermittent hypoxemia and sleep fragmentation.There is increasing emphasis on neuroimaging studies to explore underlying relationships between neuropathological changes and cognitive dysfunction.This article reviews recent research progress concerning cognitive dysfunction associated with OSA to reveal potential mechanisms that contribute to this dysfunction.
基金
Capital Funds for Health Improvement and Research(2018-1-2091)
National Natural Science Foundation of China(81970900)
Natural Science Foundation of Beijing Municipality(7194262)
Pediatric Medical Coordinated Development Center of Beijing Municipal Administration(XTZD20180101)。