新型冠状病毒肺炎密切接触者感染危险因素的Meta分析

Risk Factors for Infection in Close Contacts of COVID-19:A Meta-analysis

目的系统评价新型冠状病毒肺炎(COVID-19)密切接触者感染的危险因素。方法计算机检索Cochrane Library、Wed of Science、PubMed、Embase、CBM、WF、CNKI和VIP数据库建库至2021年1月5日有关新型冠状病毒肺炎密切接触者感染危险因素的研究,对纳入的文献进行质量评价并提取相关数据,使用RevMan5.3软件进行Meta分析。结果本研究共纳入10篇文献,共计样本量34979例,其中感染组1399例,未感染组33580例。年龄(OR=1.86,95%CI:1.63~2.13,P=0.000),接触者为患者家属(OR=12.91,95%CI:7.64~21.80,P=0.000),同住(OR=2.79,95%CI:2.05~3.80,P=0.000),同餐(OR=16.58,95%CI:10.67~25.76,P=0.000),接触频率(OR=4.33,95%CI:3.21~5.84,P=0.000),均是新型冠状病毒肺炎密切接触者感染的危险因素。结论新型冠状病毒肺炎密切接触者感染发生率高,应识别危险因素并制订预防策略,从而减少感染的发生。

Objective To systematically evaluate the risk factors of infection among close contacts of the novel coronavirus pneumonia(COVID-19).Methods Computer search of the Cochrane Library,Wed of Science,PubMed,Embase,CBM,WF,CNKI and VIP database was established until January 5,2021.Research on the risk factors of infection among close contacts of the novel coronavirus pneumonia was carried out.Quality evaluation and extraction of relevant data,using RevMan5.3 software was performed for Meta analysis.Results A total of 10 articles were included in this study,with a total sample size of 34979 cases,including 1399 cases in the infected group and 33580 cases in the uninfected group.Age(OR=1.86,95%CI:1.63-2.13,P=0.000),the contact was the patient′s family(OR=12.91,95%CI:7.64-21.80,P=0.000),living together(OR=2.79,95%CI:2.05-3.80,P=0.000),same meal(OR=16.58,95%CI:10.67-25.76,P=0.000),contact frequency(OR=4.33,95%CI:3.21-5.84,P=0.000)are the risk factors for infection in close contacts of the novel coronavirus pneumonia.Conclusion The incidence of infection among close contacts of the novel coronavirus pneumonia is high.Risk factors should be identified and prevention strategies should be developed to reduce the incidence of infection.