肺癌根治术患者血清EGFR、ALK、ROS1基因表达与预后的关系

The Relationship Between Serum EGFR,ALK and ROS1 Gene Expressions and Prognosis in Patients Undergoing Radical Resection of Lung Cancer

目的探讨肺癌根治术患者血清表皮生长因子受体(EGFR)、间接性淋巴瘤激酶(ALK)、肉瘤致癌因子1受体酪氨酸激酶(ROS1)基因表达与预后的关系,以为肺癌根治术患者预后的评估提供参考。方法收集2016年1月至2018年1月我院诊治的110例肺癌根治术患者病例资料,检测病例患者血清EGFR、ALK、ROS1基因表达情况,电话或复诊形式随访患者预后,分析肺癌根治术患者预后的影响因素,并对血清EGFR、ALK、ROS1基因表达与患者预后的关系进行相关性分析。结果110例肺癌根治术患者术前血清EGFR基因突变率为34.55%,而ALK、ROS1基因阳性表达率分别为5.45%、4.55%,术后30个月随访结果显示肺癌根治术患者复发率为22.73%,死亡率为10.00%。复发组年龄≥60岁占比、EGFR基因突变率、ALK、ROS1基因阳性表达率较无复发组明显升高(P<0.05);死亡组年龄≥60岁占比、EGFR基因突变率、ALK、ROS1基因阳性表达率较存活组明显升高(P<0.05)。年龄、EGFR基因突变、ALK、ROS1基因阳性表达是肺癌根治术患者预后的危险因素(P<0.05)。血清EGFR、ALK、ROS1基因表达与肺癌根治术患者术后复发率、死亡率呈明显正相关(P<0.05)。结论肺癌根治术患者血清EGFR基因突变和ALK、ROS1基因阳性表达是患者术后复发和死亡的影响因素,且血清EGFR基因突变和ALK、ROS1基因阳性表达与预后密切相关。

Objective To investigate the relationship between serum epidermal growth factor receptor(EGFR),anaplastic lymphoma kinase(ALK)and c-ros oncogene 1,receptor tyrosine kinase(ROS1)gene expressions and prognosis in patients undergoing radical resection of lung cancer,so as to provide a reference for prognosis of these patients.Methods The data of 110 patients who underwent radical resection of lung cancer in the hospital between January,2016 and January,2018 were collected for the study.Serum EGFR,ALK,and ROS1 gene expression levels were detected in all patients.A follow-up study was performed by telephone or subsequent visit,and the prognostic factors were analyzed.Meanwhile,the correlations between serum EGFR,ALK and ROS1 gene expressions and the prognosis were analyzed.Results In this study,the preoperative serum EGFR gene mutation rate was 34.55%,while the positive expression rates of ALK and ROS1 genes were 5.45%and 4.55%,respectively.30-month of postoperative follow-up results showed that the recurrence rate and mortality rate were 22.73%and 10.00%,respectively.The proportion of patients of≥60 years old,EGFR gene mutation rate,and positive expression rates of ALK and ROS1 gene were significantly higher in the recurrence group,compared with the non-recurrence group(P<0.05),and significantly higher in the death group than in the survival group(P<0.05).It was found that age,EGFR gene mutation,ALK and ROS1 gene positive expression were risk factors for the poor prognosis of patients undergoing radical resection of lung cancer(P<0.05).Additionally,serum EGFR,ALK,and ROS1 gene expressions were significantly positively correlated with postoperative recurrence and mortality in patients undergoing radical resection of lung cancer(P<0.05).Conclusion Serum EGFR gene mutation and positive expression of ALK and ROS1 genes in patients undergoing radical resection of lung cancer are factors affecting recurrence and death,indicating that these factors are closely related to the prognosis.