急性脑梗死患者颈动脉粥样硬化斑块形成与血清脂蛋白a、MMP-9、D-D水平相关研究

Correlation Between Carotid Atherosclerotic Plaque Formationand Serum Lipoprotein a,MMP-9,D-D Levels inPatients with Acute Cerebral Infarction

目的分析急性脑梗死患者颈动脉粥样硬化斑块形成与血清脂蛋白a、MMP-9、D-D水平的相关性。方法选择2019年1月至2020年12月间收治的150例急性脑梗死患者作为观察组,100例脑梗死但未见颈动脉粥样硬化斑块患者作为对照组;入组后检测患者血糖、血脂、脂蛋白a、MMP-9及D-D水平。结果观察组血糖、TG、TC、HDL及LDL水平均明显高于对照组,且差异具有统计学意义(P<0.05);观察组脂蛋白a、MMP-9及D-D水平均明显高于对照组,且差异具有统计学意义(P<0.05);脂蛋白a、MMP-9及D-D三指标均呈现明显的两两线性相关关系,且具有统计学意义(P<0.05);脂蛋白a、MMP-9及D-D水平与颈动脉粥样硬化斑块形成呈显著正相关关系,且具有统计学意义(P<0.01);脂蛋白a、MMP-9及D-D水平是影响颈动脉粥样硬化斑块形成的独立性危险因素(P<0.05)。结论急性脑梗死患者颈动脉粥样硬化斑块形成与血清脂蛋白a、MMP-9、D-D水平呈显著性正相关关系。

Objective To analyze the correlation between carotid atherosclerotic plaque formation and serum lipoprotein a,MMP-9,D-D levels in patients with acute cerebral infarction.Methods 150 patients with acute cerebral infarction from January 2019 to December 2020 were selected as the observation group,and 100 patients with cerebral infarction but no carotid atherosclerotic plaque were selected as the control group.After entering the group,the levels of blood glucose,blood lipid,lipoprotein a,MMP-9 and D-D were detected.Results The levels of blood glucose,TG,TC,HDL and LDL in the observation group were significantly higher than those in the control group,and the difference was statistically significant(P<0.05);the levels of lipoprotein a,MMP-9 and D-D in the observation group were significantly higher than those in the control group,and the difference was statistically significant(P<0.05);Lipoprotein a,MMP-9 and D-D showed significant linear correlation(P<0.05);the levels of lipoprotein a,MMP-9 and D-D were significantly positively correlated with the formation of carotid atherosclerotic plaque,and the difference was statistically significant(P<0.05)The levels of lipoprotein a,MMP-9 and D-D were independent risk factors for carotid atherosclerotic plaque formation(P<0.05).Conclusion There is a significant positive correlation between carotid atherosclerotic plaque formation and serum lipoprotein a,MMP-9 and D-D levels in patients with acute cerebral infarction.