乙酰半胱氨酸溶液雾化吸入联合阿奇霉素序贯疗法对小儿支原体肺炎血气分析及氧化应激指标的影响

Effects of nebulized inhalation of acetylcysteine solution combined with azithromycin sequential therapy on blood gas analysis and oxidative stress indexes in children with mycoplasma pneumonia

目的探讨乙酰半胱氨酸溶液雾化吸入联合阿奇霉素序贯疗法对小儿支原体肺炎血气分析及氧化应激指标的影响。方法选取2018年5月至2020年5月收治的80例支原体肺炎患儿作为研究对象,根据抽签法随机将其分为对照组与观察组,各40例。对照组采用阿奇霉素序贯疗法治疗,观察组采用乙酰半胱氨酸溶液雾化吸入联合阿奇霉素序贯疗法治疗。比较两组治疗前、后的血气分析、氧化应激及免疫功能指标。结果治疗后,观察组的PaCO_(2)低于对照组,PaO_(2)、SaO_(2)高于对照组(P<0.05)。治疗后,观察组的MDA水平低于对照组,SOD、GSH-Px水平高于对照组(P<0.05)。治疗后,观察组的CD3^(+)、CD4^(+)/CD8^(+)高于对照组(P<0.05)。结论乙酰半胱氨酸溶液雾化吸入联合阿奇霉素序贯疗法治疗小儿支原体肺炎有助于改善患儿的血气分析指标,减轻氧化应激反应,提高免疫功能。

Objective To explore the effects of nebulized inhalation of acetylcysteine solution combined with azithromycin sequential therapy on blood gas analysis and oxidative stress indexes in children with mycoplasma pneumonia.Methods A total of 80 children with mycoplasma pneumonia admitted from May 2018 to May 2020 were selected as the research objects and randomly divided into control group and observation group according to the drawing method,with 40 cases in each group.The control group was treated with azithromycin sequential therapy,and the observation group was treated with nebulized inhalation of acetylcysteine solution combined with azithromycin sequential therapy.Blood gas analysis,oxidative stress and immune function indexes before and after treatment were compared between the two groups.Results After treatment,PaCO_(2) in the observation group was lower than that in the control group,PaO_(2) and SaO_(2) were higher than those in the control group(P<0.05).After treatment,MDA level in the observation group was lower than that in the control group,while the levels of SOD and GSH-Px were higher than those in the control group(P<0.05).After treatment,CD3^(+)and CD4^(+)/CD8^(+)in the observation group were higher than those in the control group(P<0.05).Conclusion Nebulized inhalation of acetylcysteine solution combined with azithromycin sequential therapy in the treatment of children with mycoplasma pneumonia can help to improve the blood gas analysis indexes,reduce oxidative stress reaction and improve immune function of children.