非洲猪瘟病毒Pig/HLJ/2018株CP2475L编码蛋白pp220的生物信息学分析

Bioinformatics analysis of CP2475L gene encoding protein pp220 of African swine fever virus strain Pig/HLJ/2018

非洲猪瘟是世界动物卫生组织(OIE)的A类动物疫病,我国将其列为一类动物疫病,自2018年传入我国以来,对我国的养殖业造成巨大的冲击。pp220蛋白是非洲猪瘟病毒CP2475L基因编码的多聚蛋白前体,其经过酶解加工后形成病毒主要的结构蛋白。文章从生物信息学角度分析了pp220蛋白的基本理化特性、跨膜区、信号肽、优势B、T细胞抗原表位和构建了基于pp220蛋白的遗传进化树,通过分析结果,文章对非洲猪瘟病毒的基础数据进行了补充,以期能为非洲猪瘟防控提供基础信息和指引。

African swine fever(ASF)is an OIE class A animal disease,which is listed as a class I animal disease in China.Since its outbreak in China in 2018,it has caused huge impact on China's pig breeding industry.pp220 is a precursor polyprotein encoded by CP2475L gene of African swine fever virus(ASFV),which forms the main structural protein of ASFV after enzymatic hydrolysis and processing.This article focus on the basic physical and chemical properties,trans-membrane area,signal peptide,optimal B、T cell antigen epitopes and the genetic evolutionary realationships of Pig/HLJ/2018 pp220 protein,as a result,the basic data through those analyses of this article may provide basic information for the ASFV research,in order to provide potential suggestions for ASF prevention and control.