恩度联合同步放化疗治疗晚期肺癌的效果观察

Observation of the effect of Endo combined with concurrent radiotherapy and chemotherapy on advanced lung cancer

目的分析重组人血管内皮抑制素注射液(商品名:恩度)联合同步放化疗治疗晚期肺癌的临床效果。方法84例晚期肺癌患者,随机分为对照组和联合组,各42例。对照组患者采用同步放化疗治疗,联合组患者采用恩度联合同步放化疗治疗。比较两组患者临床疗效、不良反应发生情况及生存质量评分。结果联合组治疗总有效率为76.19%,显著高于对照组的47.62%,差异有统计学意义(P<0.05)。联合组不良反应发生率33.33%与对照组的40.48%比较,差异无统计学意义(P>0.05)。治疗前,两组生存质量评分比较,差异无统计学意义(P>0.05);治疗后,两组生存质量评分明显高于治疗前,且联合组生存质量评分(74.20±3.20)分明显高于对照组的(60.50±2.50)分,差异有统计学意义(P<0.05)。结论恩度联合同步放化疗治疗晚期肺癌不良反应发生情况与同步放化疗接近,并在协同基础上提升了治疗效果与患者生活质量。

Objective To analyze the clinical effect of recombinant human endostatin injection(trade name:Endo)combined with concurrent radiotherapy and chemotherapy on advanced lung cancer.Methods A total of 84 patients with advanced lung cancer were randomly divided into control group and combination group,with 42 cases in each group.Patients in the control group were treated with concurrent radiotherapy and chemotherapy,and patients in the combination group were treated with Endo and concurrent radiotherapy and chemotherapy.The clinical efficacy,occurrence of adverse reactions and quality of life of the two groups were compared.Results The total effective rate 76.19%of combination group was significantly higher than 47.62%of the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions 33.33%of combination group had no statistically significant difference compared with 40.48%of the control group(P>0.05).Before treatment,there was no statistically significant difference in quality of life score between the two groups(P>0.05).After treatment,the quality of life score of the two groups were obviously higher than those before treatment,and the quality of life score(74.20±3.20)points of combination group was obviously higher than(60.50±2.50)points of the control group.All the difference was statistically significant(P<0.05).Conclusion Combination of Endo and concurrent radiotherapy and chemotherapy is similar to the occurrence of adverse reactions of concurrent radiotherapy and chemotherapy,and it can improve the treatment effect and the quality of life of patients on the basis of synergy.