还原型谷胱甘肽治疗病毒性肝炎的临床疗效探讨

Clinical efficacy of reductive glutathione in the treatment of viral hepatitis

目的分析还原型谷胱甘肽治疗病毒性肝炎的临床疗效。方法70例病毒性肝炎患者,采用随机数字表法分为常规组和还原型谷胱甘肽组,每组35例。常规组患者给予常规治疗,还原型谷胱甘肽组在常规组基础上增加还原型谷胱甘肽治疗。比较两组患者治疗前后肝功能指标及临床疗效。结果治疗后,两组患者PTA水平均高于本组治疗前,AST、TBIL、ALT水平均低于本组治疗前,且还原型谷胱甘肽组PTA水平高于常规组,AST、TBIL、ALT水平均低于常规组,差异具有统计学意义(P<0.05)。还原型谷胱甘肽组治疗总有效率94.29%高于常规组的74.29%,差异具有统计学意义(χ^(2)=5.285,P=0.022<0.05)。结论常规联合还原型谷胱甘肽对于病毒性肝炎的治疗效果确切,可更好提高治疗效果和改善患者肝功能,值得推广应用。

Objective To analyze the clinical efficacy of reductive glutathione in the treatment of viral hepatitis.Methods A total of 70 patients with viral hepatitis were randomly divided into conventional group and reductive glutathione group,with 35 patients in each group.Patients in the conventional group were treated with conventional means,and patients in the reductive glutathione group were treated with reductive glutathione in addition to the conventional treatment.The liver function index before and after the treatment and clinical efficacy were compared between two groups.Results After the treatment,the level of PTA in both groups was higher than that before the treatment,the levels of AST,TBIL,ALT in conventional groups were lower than those before the treatment;the level of PTA in the reductive glutathione groups was higher than that in the conventional group,the levels of AST,TBIL,ALT were lower than those in the conventional group.All the differences were statistically significant(P<0.05).The total efficacy rate of reductive glutathione group was 94.29%,which was higher than 74.29%of the conventional group,and the difference was statistically significant(χ^(2)=5.26,P=0.022<0.05).Conclusion Conventional means combined with reductive glutathione shows a reliable therapeutic effect on viral hepatitis,which can better improve therapeutic effect and liver function of patients,thus it is worthy of promotion and application.