米非司酮联合安宫黄体酮治疗人流后宫腔残留的疗效观察

Efficacy observation of mifepristone combined with medroxyprogesterone 17-acetate in the treatment of intrauterine residue after induced abortion

目的分析米非司酮联合安宫黄体酮治疗人工流产(人流)后宫腔残留的临床疗效。方法120例人流后宫腔残留患者,随机分为对照组和观察组,各60例。对照组患者采用安宫黄体酮治疗,观察组患者采用米非司酮联合安宫黄体酮治疗。比较两组患者治疗效果、不良反应发生情况及止血时间、生活质量。结果观察组治疗总有效率95.00%明显高于对照组的80.00%,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。观察组出血控制时间(3.60±0.80)d及完全止血时间(6.10±1.20)d,均短于对照组的(6.05±1.05)、(8.20±1.50)d,差异有统计学意义(P<0.05)。治疗后,观察组生活质量评分(94.50±3.30)分明显高于对照组的(85.50±3.20)分,差异有统计学意义(P<0.05)。结论米非司酮联合安宫黄体酮治疗人流后宫腔残留止血效果好、安全性高、加速了患者出血控制与止血时间,提升患者生活质量。

Objective To analyze clinical efficacy of mifepristone combined with medroxyprogesterone 17-acetate in the treatment of intrauterine residue after induced abortion.Methods A total of 120 patients with intrauterine residue after induced abortion were randomly divided into control group and observation group,with 60 cases in each group.The control group was treated with medroxyprogesterone 17-acetate,and the observation group was treated with mifepristone and medroxyprogesterone 17-acetate.The therapeutic effect,occurrence of adverse reactions,hemostasis time and quality of life were compared between the two groups.Results The total effective rate 95.00%of the observation group was obviously higher than 80.00%of the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in incidence of adverse reactions between the two groups(P>0.05).The bleeding control time(3.60±0.80)d and complete hemostasis time(6.10±1.20)d of the observation group were shorter than(6.05±1.05)and(8.20±1.50)d of the control group,and the difference was statistically significant(P<0.05).After treatment,the quality of life(94.50±3.30)points of the observation group was obviously higher than(85.50±3.20)points of the control group,and the difference was statistically significant(P<0.05).Conclusion Combination of mifepristone and medroxyprogesterone 17-acetate has good hemostasis effect and high safety in the treatment of intrauterine residue after induced abortion,which accelerates the bleeding control and hemostasis time of patients,and helps improve the quality of life of patients.