基于NLRP3炎症小体探讨中医药防治溃疡性结肠炎的机制

Mechanism of Chinese herbal medicine treatment of ulcerative colitis via nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome

溃疡性结肠炎(ulcerative colitis,UC)是一种病因不明、易反复的慢性非特异性肠道疾病[1],其增加结直肠癌的风险已被证实[2]。近期Ola Olén团队在柳叶刀上发表的研究表明,UC患者结直肠癌的发病率和死亡率显著高于非UC患者[3],严重威胁着人们的生命健康。目前,氨基水杨酸类、皮质类固醇和免疫抑制剂等为轻、重度UC的治疗药物。一般认为UC的潜在发病机制为:免疫介导的慢性肠道非可控性炎症,导致肠黏膜屏障损伤。

Ulcerative colitis(UC) is an unexplained, recurrent,chronic nonspecific intestinal disease,and chronic colitis has been shown to increase the risk of colorectal cancer.Many studies have reported that nucleotide-binding oligomerization domain-like receptor protein 3(NLRP3)inflammasome is closely related to the development of UC.Therefore,NLRP3 inflammasome are likely to become a new target for the treatment of UC.Chinese herbal medicine has the characteristics of multi-target,multi-function and multi-pathway against inflammatory,cancer and immunological diseases.This review provides a further understanding of the key mechanisms of Traditional Chinese Medicine in the regulation of NLRP3 inflammasome and demonstrates new ideas and directions for treatment of UC.