慢性鼻病与T淋巴细胞亚群的相关研究

Study on Correlation between Chronic Rhinopathy and T Lymphocyte Subsets

目的:探究慢性鼻病与T淋巴细胞亚群的相关性。方法:选取2018年10月-2019年10月的200例慢性鼻病患者为观察组,同时期的50名体检健康者为对照组。检测并比较两组的外周血T淋巴细胞亚群(CD3^(+)、CD4^(+)、CD8^(+)及CD4^(+)/CD8^(+)),并比较观察组中不同疾病分类、严重程度及复发情况者的上述检测结果,采用Spearman秩相关分析T淋巴细胞亚群与严重程度的关系,采用Pearson相关性分析T淋巴细胞亚群与疾病分类及复发情况的关系。结果:观察组的CD3^(+)、CD4^(+)及CD4^(+)/CD8^(+)均显著低于对照组,CD8^(+)显著高于对照组,差异均有统计学意义(P<0.05)。观察组中过敏性鼻炎患者和复发患者的CD3^(+)、CD4^(+)及CD4^(+)/CD8^(+)均显著低于慢性鼻窦炎患者和未复发患者,CD8^(+)显著高于慢性鼻窦炎患者和未复发患者,差异均有统计学意义(P<0.05)。观察组中不同严重程度者的外周血T淋巴细胞亚群比较,差异均有统计学意义(P<0.05)。CD3^(+)、CD4^(+)及CD4^(+)/CD8^(+)均随着严重程度的加重而减少,CD8^(+)随着严重程度的加重而增加,差异均有统计学意义(P<0.05)。Spearman秩相关分析显示CD3^(+)、CD4^(+)及CD4^(+)/CD8^(+)与严重程度呈负相关,CD8^(+)与严重程度呈正相关(P<0.05)。Pearson相关性分析显示T淋巴细胞亚群与疾病分类及复发情况密切相关(P<0.05)。结论:慢性鼻病与T淋巴细胞亚群密切相关,且不同疾病分类、严重程度及复发情况者的差异显著,应充分重视慢性鼻病患者T淋巴细胞亚群的检测与干预。

Objective:To explore the correlation between chronic rhinopathy and T lymphocyte subsets.Method:A total of 200 patients with chronic rhinopathy from October 2018 to October 2019 were selected as the observation group,and 50 healthy subjects during the same period were selected as the control group.The peripheral blood T lymphocyte subsets(CD3^(+),CD4^(+),CD8^(+)and CD4^(+)/CD8^(+))of two groups were detected and compared,and the above detection results of different classification,severity and recurrence in the observation group were compared.Spearman rank correlation was used to analyze the relationship between T lymphocyte subsets and severity.The relationship between T lymphocyte subsets and disease classification and recurrence was analyzed by Pearson correlation.Result:CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)in the observation group were significantly lower than those in the control group,while CD8^(+)was significantly higher than that in the control group,the differences were statistically significant(P<0.05).In the observation group,CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)of allergic rhinitis patients and recurrent patients were significantly lower than those of chronic sinusitis patients and non-recurrent patients,while CD8^(+)was significantly higher than those of chronic sinusitis patients and non-recurrent patients,the differences were statistically significant(P<0.05).Comparison of T lymphocyte subsets in peripheral blood of patients with different degrees of severity in observation group,the differences were statistically significant(P<0.05).CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)all decreased with the aggravation of severity,while CD8^(+)increased with the aggravation of severity,the differences were statistically significant(P<0.05).Spearman rank correlation analysis showed that CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)were negatively correlated with severity,while CD8^(+)was positively correlated with severity(P<0.05).Pearson correlation analysis showed that T lymphocyte subsets were closely related to disease classification and recurrence(P<0.05).Conclusion:Chronic rhinopathy is closely related to T lymphocyte subsets,and there are significant differences among different disease categories,severity and recurrence.Therefore,full attention should be paid to the detection and intervention of T lymphocyte subsets in patients with chronic rhinopathy.