摘要
目的:观察扫白茴风丸治疗阳虚血瘀型白癜风的临床疗效及对皮肤表面金黄色葡萄球菌定植率的影响。方法:根据纳入、排除标准将中医辨证为阳虚血瘀型白癜风的120例患者采用随机对照分组的方法分为治疗组60例(口服中药经验方扫白茴风丸),对照组60例(口服中成药白癜风丸),连续服药4个月后进行疗效对比及药物安全评估;根据临床检验操作规程进行治疗前后皮损处和背部常规菌种鉴定,并选取正常组30例(健康体检者)进行比较,观察记录治疗前后正常组与治疗组皮肤表面金黄色葡萄球菌的阳性率变化。结果:治疗4个月后,治疗组总有效率为91%(52/57),疗效优于对照组的总有效率71%(40/56),疗效差异显著(P<0.05);白癜风患者皮肤表面金黄色葡萄球菌定植率高于正常人水平(P<0.05),且背部数值最高;经扫白茴风丸4个月的治疗后患者皮损处及背部金黄色葡萄球菌定植率较治疗前都有所下降(P<0.05)。结论:扫白茴风丸能明显减少阳虚血瘀型白癜风患者的皮损面积,降低皮肤表面金黄色葡萄球菌的定植率。
Objective:To observe the clinical effect of Saobai Huifeng Pill in treating vitiligo of Yang deficiency and blood stasis syndrome and its influence to Staphylococcus aureus colonization rate on the skin surface of the patients.Methods:According to the inclusion and exclusion criteria,120 cases of vitiligo with syndrome differentiation of Yang deficiency and blood stasis were randomly divided into the treatment group(Saobai Huifeng Pill)and the control group(Biandianfeng Pill),with 60 cases in each group.After 4 months of the treatments,efficacy and safety of the medications were evaluated and compared.According to the operation procedures of the clinical test,routine bacterial identification was carried out.Another 30 healthy people were taken as the normal control.The positive rate of Staphylococcus aureus in skin was compared between the treatment group and the normal control group before and after the intervention.Results:After 4 months of the treatment,the total effective rate of the treatment group was 91%(52/57),which was significantly higher than 71%(40/56)of the control group(P<0.05).The colonization rate of Staphylococcus aureus was higher in vitiligo patients than that of the normal people(P<0.05),and the rate of lower back was the highest.After 4 months of the treatment with Saobai Huifeng Pill,the colonization rate of Staphylococcus aureus in skin and back of the patients decreased significantly compared to that before the treatment(P<0.05).Conclusion:Saobai Huifeng Pill can obviously improve the area of skin lesions in vitiligo patients with Yang deficiency and blood stasis syndrome,and reduce the colonization rate of Staphylococcus aureus.
作者
王远红
董晓仪
李玉
WANG Yuanhong;DONG Xiaoyi;LI Yu(The First Affiliated Hospital of Heilongjiang Universit of Chinese Medicine,Harbin 150040,China;Heilongjiang University of Chinese Medicine,Harbin 150040,China;Heilongjiang Provincial Hospital of Traditional Chinese Medicine,Harbin 150036,China)
出处
《中医药学报》
CAS
2021年第8期60-64,共5页
Acta Chinese Medicine and Pharmacology
基金
国家自然科学基金面上项目(81873312)
教育部2018年度春晖计划项目(Z2008-1-15022)
黑龙江省自然科学基金面上项目(H201462)
哈尔滨市科技创新人才研究专项资金项目(2016RAXYJ102)。
关键词
白癜风
阳虚血瘀型
扫白茴风丸
金黄色葡萄球菌
Vitiligo
Yang deficiency and blood stasis
Saobai Huifeng Pill
Staphylococcus aureus