冠心病秽浊痰阻证患者血清代谢特征分析

Characteristics of Serum Metabolism in Patients with CHD of Turbidity Phlegm Obstruction Syndrome

目的:探索冠心病(CHD)秽浊痰阻证患者血清代谢特征。方法:选取2017年5月—2019年5月于新疆医科大学附属中医医院住院的冠心病患者402例,另设健康对照组225例,共627例。比较CHD秽浊痰阻证患者血清代谢特征。结果:402例CHD患者中秽浊痰阻证患者228例,占CHD总人数56.72%(228/402);CHD秽浊痰阻证、非秽浊痰阻证患者的年龄、收缩压(SBP)、舒张压(DBP)、体质指数(BMI)、腹围(WC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、空腹血糖(FBG)、糖化血红蛋白(HbA1c)及血尿酸(UA)水平均显著高于健康对照组(P<0.05,P<0.01),且冠心病秽浊痰阻证患者的血清总胆固醇(TC)及纤维蛋白原(FIB)水平高于非秽浊痰阻证组及健康对照组(P<0.05)。结论:秽浊痰阻证是新疆CHD患者的主要症候类型,肥胖、血脂紊乱、血糖异常、尿酸及纤维蛋白原水平升高与CHD秽浊痰阻证的发生关系密切。

Objective:To explore the characteristics of serum metabolism in patients with coronary heart disease(CHD)of turbid phlegm obstruction syndrome.Methods:A total of 402 patients with CHD were included in the study,and 225 healthy people were taken as the control.The characteristics of serum metabolism in patients with CHD of turbid phlegm obstruction were compared to those in the other people.Results:Among the 402 CHD patients,there were 228 patients with turbid phlegm obstruction syndrome,accounting for 56.72%(228/402)of the total number of CHD.The levels of age and systolic blood pressure(SBP),diastolic blood pressure(DBP),body mass index(BMI),abdominal circumference(WC),triglycerides(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),fasting blood glucose(FBG),glycosylated hemoglobin(HbA1c)and blood uric acid(UA)were all significantly higher than those of the healthy control group(P<0.05,P<0.01),and the serum levels of total cholesterol(TC)and fibrinogen(FIB)were higher in the turbid phlegm obstruction syndrome group than those in the non-turbid phlegm obstruction syndrome group and the healthy control group(P<0.05).Conclusion:The turbid phlegm obstruction syndrome is the main symptom type of CHD patients in Xinjiang.Obesity,dyslipidemia,abnormal blood sugar and elevated levels of uric acid and fibrinogen are closely related to the occurrence of turbid phlegm obstruction syndrome in CHD.