补阳还五汤防治脑缺血再灌注损伤的研究进展

Research Progress in Preventing and Treating CIRI with Buyang Huanwu Decoction

补阳还五汤是益气活血的代表方,其根据气虚血瘀理论而立,具有补气行血、活血化瘀的作用,广泛应用于缺血性脑卒中的临床防治。梗死组织周边缺血半暗带的恢复再通是缺血性脑卒中的首选治疗方法,然而脑血流再灌注会引起一系列的病理过程,这被称为脑缺血再灌注损伤(CIRI)。研究显示,CIRI主要通过脑神经元兴奋性氨基酸毒性增强、钙超载、氧自由基损伤、炎症反应、细胞凋亡等途径造成神经细胞损伤。补阳还五汤可以通过抑制兴奋性氨基酸毒性、减轻钙超载、抑制氧自由基损伤、减轻炎症反应、抑制细胞凋亡等防治CIRI。本文研究近年来发表的补阳还五汤防治CIRI的相关文献,现将其研究进展进行综述。

Buyang Huanwu Decoction is a representative prescription for invigorating Qi and promoting blood circulation.It was established based on the theory of Qi deficiency and blood stasis,and has the functions of nourishing Qi,promoting blood circulation and removing blood stasis.It is widely used in the clinical prevention and treatment of ischemic stroke.Recovery and recanalization of the ischemic penumbra surrounding the infarcted tissue is the preferred treatment for ischemic stroke.However,cerebral blood flow reperfusion leads to a series of pathological processes,known as cerebral ischemia-reperfusion injury(CIRI).Studies have shown that CIRI is mainly caused by neurogenic amino acid toxicity enhancement,calcium overload,oxygen free radical damage,inflammatory response and cell apoptosis.Buyang Huanwu Decoction can reduce CIRI by inhibiting excitatory amino acid toxicity,reducing calcium overload,inhibiting oxygen free radical damage,reducing inflammatory response and inhibiting cell apoptosis.This study reviewed Buyang Huanwu Decoction in preventing and treating CIRI by studying relevant published literature in recent years.