青寒退热方加减治疗小儿急性上呼吸道感染风热证临床研究

Clinical Study on Modified Qinghan Tuire Decoction in Treatment of Children Acute Upper Respiratory Tract Infection with Wind-heat Syndrome

目的观察青寒退热方加减治疗小儿急性上呼吸道感染风热证临床疗效。方法采用随机数字表法将200例患儿分为观察组和对照组各100例。观察组予青寒退热方加减,对照组予银翘散加减,每日1剂,每日2~3次,口服。2组疗程均为5 d,随访1个月。观察2组临床疗效,比较2组完全解热时间、治疗前后中医症状积分及随访时感染后咳嗽发生率。结果观察组脱落3例,剔除1例;对照组脱落10例,剔除3例。观察组总有效率为98.96%(95/96),对照组为94.25%(82/87),2组比较差异无统计学意义(P>0.05)。观察组完全解热时间为(21.17±8.52)h,对照组为(26.68±13.53)h,2组比较差异有统计学意义(P<0.05)。与本组治疗前比较,2组治疗后中医症状积分明显下降(P<0.05);2组治疗后比较,观察组中医症状积分明显低于对照组(P<0.05)。随访时观察组感染后咳嗽发生率低于对照组(P<0.05)。结论青寒退热方加减与银翘散加减治疗小儿急性上呼吸道感染风热证均具有一定临床疗效,前者在缩短解热时间、减少感染后咳嗽并发症方面更具优势。

Objective To evaluate clinical efficacy of Qinghan Tuire Decoction in the treatment of children acute upper respiratory tract infection with wind-heat syndrome.Methods Totally 200 children with acute upper respiratory tract infection with wind-heat syndrome were divided into observation group and control group according to random number table method,with 100 cases in each group.The observation group was treated with modified Qinghan Tuire Decoction,and the control group was treated with modified Yinqiao Powder,one dosage per day,twice or three times a day,orally.The treatment course of the two groups was 5 days,and the follow-up was 1 month.The clinical efficacy of the two groups was observed,and the time of complete antipyretic,TCM symptom scores before and after treatment and the incidence of cough after infection of follow-up in both groups were compared.Results In the observation group,3 cases were lost and 1 case was eliminated.In the control group,10 cases were lost and 3 cases were eliminated.The total effective rate in the observation group was 98.96%(95/96),and the rate in the control group was 94.25%(82/87).There was no statistical significance between the two groups(P>0.05).The time of complete antipyretic in the observation group was(21.17±8.52)h,and the control group was(26.68±13.53)h,with statistical significance(P<0.05).Compared with before treatment,the TCM symptom scores of the two groups decreased significantly after treatment(P<0.05);after treatment,the TCM symptom score of the observation group was significantly lower than that of the control group(P<0.05).During the follow-up,the incidence of cough after infection in the observation group was lower than that in the control group(P<0.05).Conclusion Both modified Qinghan Tuire Decoction and modified Yinqiao Powder have certain clinical efficacy in treating children with acute upper respiratory tract infection with wind-heat syndrome.The former has advantages in shortening the antipyretic time and reducing the complications of coughing after infection.