病证结合动物模型研究思路述评

A Review of Research Ideas in Combination of Disease and Syndrome Animal Models

病证结合动物模型是中西医结合基础研究的有效工具,在模型运用过程中仍有部分问题亟待解决。本文总结现阶段两类病证结合动物模型研究思路,对病因与证因的时序性关系、正向评价与逆向反证的可信度关系、不施加证因的合理性等研究中涉及的问题进行论述,提出相应的发展思路,以期为进一步研究提供借鉴。

Animal models of combination of disease and syndrome are an effective tool for basic research on the integrated traditional Chinese and Western medicine.However,some problems still need to be solved in the application of the models.This article concluded the research ideas of two types of animal models of combination of disease and syndrome,discussed the key issues involved in the research,such as temporal relationship between the cause of disease and syndrome,credibility of positive evaluation and negative evidence,and reasonability without the cause of syndrome,etc.,and put forward corresponding development ideas,in order to provide references for further research.