调节自噬治疗神经病理性疼痛的药物研究进展

Advances in drug research on the treatment of neuropathic pain by regulating autophagy

神经病理性疼痛是一种由于神经系统损伤引起的慢性疼痛,由于其机制复杂,神经病理性疼痛的治疗仍是全世界健康问题的重大挑战。近来研究表明自噬功能障碍是神经性疼痛发生发展的病理中理学基础,且通过调节自噬可以减轻神经病理性疼痛。笔者以自噬与神经病理性疼痛的机制为切入点,对调节自噬治疗神经病理性疼痛的药物进行综述,以期为该疾病的药物治疗提供参考。

Neuropathic pain is a kind of chronic pain caused by nervous system injury.Rerause of its complex mechanism,the1 treatment of neuropathic pain is still a major challenge to health problems all over the world.Recent studies have shown that autophagy dysfunction is the pathophysiological basis for the occurrence and development of neuropathic pain,and neuropathic pain can be alleviated by regulating autophagy.Based on the mechanism of autophagy and neuropathic pain,this paper reviews the drugs that regulate autophagy in the treatment of neuro-pathic pain,in order to of this disease.