尿路微生物与膀胱癌的相关性研究进展

Research progress on the relationship between urinary tract microbiome and bladder cancer

膀胱癌是泌尿系统的常见恶性肿瘤,我国的膀胱癌发病率和病死率一直处于较高水平。过去人们普遍认为膀胱是无菌环境,但目前已发现膀胱中存在共生的微生物,并且尿液中微生物和其代谢产物可能参与多种泌尿系统疾病如膀胱癌的发生和发展。同时,微生物及其成分制品如卡介苗在治疗膀胱癌方面也占有重要地位。该文就尿路微生物与膀胱癌的发生、发展和治疗的相关研究进展进行综述,旨在为膀胱癌的早诊早治、防控及预后评估提供新思路。

Bladder cancer is a common malignant tumor of the urinary system.The incidence and mortality of bladder cancer in China have been at a high level.In the past,people generally believed that the bladder was a sterile environment,but it has been found that there are symbiotic microorganisms in the bladder.In addition,microorganisms and their metabolites in urine may be involved in the occurrence and development of various urinary system diseases such as bladder cancer.At the same time,microorganisms and their component products such as Bacillus Calmette-Guerin vaccine play an important role in the treatment of bladder cancer.This article reviews the research progress of urinary tract microorganisms and the occurrence,development and treatment of bladder cancer,and aims to provide new ideas for the early diagnosis and treatment,prevention and prognosis evaluation of bladder cancer.