托吡酯片、丙戊酸钠对老年癫痫患者脑电图的影响观察

Effect of Topiramate Tablets and Valproate on EEG in Elderly Patients With Epilepsy

目的探究托吡酯片、丙戊酸钠对老年癫痫患者脑电图(EEG)的影响。方法选取78例老年癫痫患者为受试对象,使用随机数字表法分为研究组与对照组各39例。对照组予以丙戊酸钠,研究组予以托吡酯片进行治疗。比较两组患者治疗前及治疗3个月后癫痫发作频率、发作持续时间、EEG检查(痫样放电、累及导联数)变化情况,比较两组患者治疗期间内不良反应发生情况。结果治疗3个月后,两组患者癫痫发作频率和发作持续时间较治疗前下降,且研究组低于同期对照组(P<0.05);两组患者痫样放电、累及导联数较治疗前下降,且研究组低于同期对照组(P<0.05);两组患者在治疗期间不良反应情况差异无统计学意义(P>0.05)。结论托吡酯片对老年癫痫患者疗效较丙戊酸钠更优,对脑电图的改善更明显,安全性较好,有利于其预后恢复。

Objective To investigate the effect of topiramate tablets and sodium valproate on electroencephalogram(EEG)in elderly patients with epilepsy.Methods A total of 78 elderly patients with epilepsy were selected as the test subjects.They were divided into a study group and a control group by using random number table,39 cases each.The control group was treated with sodium valproate,and the research group was treated with topiramate tablets.The changes in seizure frequency,duration of seizures,and EEG tests(epileptic discharge,number of leads involved)were compared before and after 3 months of treatment in the two groups.Results After 3 months of treatment,the frequency of seizures and duration of seizures in the two groups were lower than before treatment,and the study group was lower than the control group over the same period(both P<0.05).The number of epilepsy-like discharges and the number of leads involved in the two groups were lower than before treatment,and the study group was lower than the control group over the same period(both P <0.05).There was no significant difference in adverse reactions between the two groups during the treatment(both P>0.05).Conclusion Topiramate tablets are more effective than sodium valproate in elderly patients with epilepsy,and have more obvious improvements in EEG.They are safer and are beneficial to their prognosis.