丹参川芎嗪联合低分子肝素钙预防性用药在股骨颈骨折术后患者并发下肢深静脉血栓中的应用观察

Application of Prophylactic Usage of Danshen Chuanxiongqin Combined with Low-molecular Weight Heparin Calcium in Deep Vein Thrombosis of Patients After Femoral Neck Fracture Surgery

目的观察丹参川芎嗪联合低分子肝素钙预防性用药在股骨颈骨折术后患者并发下肢深静脉血栓(DVT)中的应用效果。方法选择就诊并接受股骨颈骨折手术治疗的60例患者,按随机数表法分为观察组30例和对照组30例。对照组注射低分子肝素钙,观察组再在对照组基础上同时注射丹参川芎嗪。观察两组术后DVT的发生情况、相关指标变化以及不良反应。结果治疗后,观察组DVT发生率为3.33%,对照组为16.67%,差异无统计学意义(P>0.05);观察组凝血指标改善程度优于对照组(P<0.05);观察组炎性因子改善情况优于对照组(P<0.05);两组均无不良反应发生。结论应用丹参川芎嗪联合低分子肝素钙能够有效降低股骨颈骨折手术治疗患者的凝血风险,同时降低患者的炎症水平,安全性好。

Objective To observe the application effect of prophylactic usage of Danshen Chuanxiongqin combined with lowmolecular weight heparin(LMWH)calcium in deep vein thrombosis(DVT)of patients after femoral neck fracture surgery. Methods Sixty patients who were treated and underwent femoral neck fracture surgery were enrolled.They were divided into observation group(Danshen Chuanxiongqin combined with LMWH calcium)and control group(LMWH calcium)by random number table method,30 cases in each group.The occurrence of postoperative DVT,changes of related indexes,and adverse reactions in both groups were observed. Results After treatment,the difference in incidence of DVT between observation group and control group was not statistically significant(3.33% vs 16.67%)(P>0.05).The improvement of coagulation indexes in observation group was better than that in control group(P<0.05),and improvement of inflammatory factors was better than that in control group(P<0.05).There was no adverse reactions in either group. Conclusion The application of Danshen Chuanxiongqin combined with LMWH calcium can effectively reduce coagulation risk in patients undergoing femoral neck fracture surgery,and reduce inflammation level,with good safety.