阿奇霉素联合丙种球蛋白治疗儿童百日咳的效果观察

Observation on Effects of Azithromycin Combined With Gamma Globulin in the Treatment of Pertussis in Children

目的研究观察阿奇霉素(AZM)联合丙种球蛋白(HGG)治疗儿童百日咳的效果。方法选取78例患儿百日咳患儿随机分为单一组与联合组。单一组患儿39例,应用AZM治疗;联合组39例,应用AZM联合HGG治疗。比较治疗5 d后,两组患儿痉挛性咳嗽症状消失时间、鸡啼样吸气性吼声消失时间、住院时间差异,比较治疗前及治疗5 d后肺功能[达峰时间比(TPTEF/TE)、达峰容积比(VPEF/VE)]水平指标变化,分析疗程内两组患儿不良反应发生情况。结果联合组痉挛性咳嗽消失时间、鸡啼样吸气性吼声消失时间、住院时间均明显少于单一组(P<0.05)。治疗5 d后,两组TPTEF/TE、VPEF/VE水平均较治疗前有显著升高,且联合组明显高于单一组(P<0.05)。治疗过程中,两组患儿不良反应发生率比较无统计学意义(P>0.05)。结论 AZM联合HGG应用治疗儿童百日咳效果明显,可促进患儿症状消失,且并未明显增加药物副作用发生率,适宜临床推广应用。

Objective To study and observe the effects of azithromycin(AZM)combined with human gamma globulin(HGG)in the treatment of pertussis in children.Methods Totally 78 children patients with pertussis admitted to our hospital from January2017 to December 2019 were randomly divided into single group(n=39,treated with AZM)and combined group(n=39,treated with AZM combined with HGG).After 5 d of treatment,differences in disappearance time of spastic cough symptoms,disappearance time of crow-like inspiratory roar and hospital stay were compared between the two groups.The lung function indexes [time to peak ratio(TPTEF/TE),peak volume ratio(VPEF/VE)] were compared before treatment and after 5 d of treatment.The occurrence of drug side effects were analyzed in the two groups during the course of treatment.Results The disappearance time of spastic cough,disappearance time of crow-like inspiratory roar and hospital stay in combined group were significantly shorter than those in single group(P<0.05).After 5 d of treatment,the levels of TPTEF/TE and VPEF/VE in the two groups were significantly higher than those before treatment,and the levels in combined group were significantly higher than those in single group at the same time point(P<0.05).During the course of treatment,there were no significant differences in the drug side effects between the two groups(P>0.05).Conclusion AZM combined with HGG has a significant effect in treating pertussis in children,and it can promote the disappearance of symptoms,and does not significantly increase the incidence rates of drug side effects.Thus it is suitable for popularization and application.