摘要
A recently disclosed Erk-induced PARP1 activation mediates the expression of immediate early genes(IEG)in response to a variety of extra-and intra-cellular signals implicated in memory acquisition,development and proliferation.Here,we review this mechanism,which is initiated by stimulation-induced binding of PARP1 to phosphorylated Erk translocated into the nucleus.Their binding maintains their long-lasting activity in a synergism,which offers a new pattern for targeted therapy.
基金
Our research was supported by the Israel Science Foundation
the Israeli Ministry of Health and NIH grant 1R21DA027776(M.C.-A.)
The Pascal lab is supported by CIHR grant BMA342854(J.M.P).
