定量药品获益-风险评价方法研究及启示

Current Research on Quantitative Drug Benefit-Risk Assessment Methods and Its Englightenment

目的介绍目前定量药品获益-风险评价方法的基本原理和最新进展。方法查阅目前药品获益-风险评价相关指导原则和系统检索中外有关定量药品获益-风险评价方法文献进行综述。结果简要介绍几种理论依据较为充分的不同类别的定量药品获益-风险评价方法,分析和讨论定量药品获益-风险评价方法的应用现状和发展趋势。结论目前在定量药品获益-风险评价方法的选择与使用上尚未形成统一共识,较为新颖的方法尚未得到广泛应用,仍需真实世界药品评价的进一步检验。

Objective To introduce the basic principles and latest developments of current quantitative drug benefit-risk assessment methods.Methods Current guidelines for drug benefit-risk assessment were consulted while domestic and foreign literature on quantitative drug benefit-risk assessment methods was retrieved to conduct a literature review.Results Several well-grounded quantitative benefit-risk assessment methods were outlined.The current applications of quantitative benefit-risk assessment methods of drugs were analyzed and the developments of quantitative assessment methods were explored.Conclusion There is no specific consensus on the selection and use of quantitative drug benefit-risk assessment methods.The relatively novel methods have not been widely used and need to be verified and confirmed in the real drug benefit-risk assessment context.