外周血嗜酸性粒细胞计数在急性荨麻疹住院患者中的临床意义

Clinical significance of peripheral blood eosinophil counts in hospitalized patients with acute urticaria

目的研究60例急性荨麻疹住院患者的外周血嗜酸性粒细胞(EOS)计数与患者全身症状(呼吸困难、腹痛等)、白细胞(WBC)计数、中性粒细胞(NEUT)计数、血红蛋白(Hb)、C反应蛋白(CRP)、红细胞沉降率(ESR)、甲状腺功能的相关性。方法收集2014年9月至2020年6月上海交通大学医学院附属仁济医院和南京医科大学附属无锡第二人民医院皮肤科收治入院的急性荨麻疹患者60例,根据EOS计数将60例患者分为EOS减少组(减少组)和对照组。分析两组患者全身症状、WBC、NEUT、Hb、CRP、ESR、甲状腺功能的差异。结果减少组和对照组各30例。减少组86.7%(26/30)的患者有全身症状,主要为呼吸困难。减少组的全身症状发生率明显高于对照组(P<0.01);减少组患者的WBC、NEUT以及CRP水平均较对照组增高(P<0.01),而Hb、ESR差异无统计学意义(P>0.05);减少组患者甲状腺功能异常者明显增多;相关性分析表明患者的外周血EOS计数与WBC、NEUT、CRP呈负相关(r=-0.380、-0.468、-0.351,P<0.01)。结论急性荨麻疹患者在发病期存在外周血EOS计数减少的现象,外周血EOS计数减少的患者全身症状发生率高,相关实验室指标异常者多,应予以重视。

Objective To study the correlation between the peripheral blood eosinophil(EOS)counts with the systemic symptoms(dyspnea,abdominal pain,etc.),white blood cell count(WBC),neutrophil count(NEUT),hemoglobin(Hb),C-reactive protein(CRP),erythrocyte sedimentation rate(ESR),and thyroid function of 60 hospitalized patients with acute urticaria.Methods Sixty inpatients with acute urticaria were collected from the dermatology department of Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and Affiliated Wuxi Second People′s Hospital of Nanjing Medical University from September 2014 to June 2020.The patients were divided into the reduction group and control group based on the EOS count.The differences in the systemic symptoms,WBC,NEUT,Hb,CRP,ESR and thyroid function between the two groups were analyzed.Results The reduction group and control group each had 30 cases.86.7%(26/30)cases in the reduction group had the systemic symptoms,which was dominated by dyspnea,the incidence rate of the systemic symptoms in the reduction group was significantly higher than that in the control group(P<0.01).The blood WBC,NEUT and CRP levels in the reduction group were increased compared with those in the control group(P<0.01),while the difference in the Hb and ESR levels had no statistical significance(P>0.05).The number of the cases with abnormal thyroid function in the reduction group was significantly increased.The correlation analysis showed that the peripheral blood EOS count was negatively correlated with the blood WBC,NEUT and CRP(r=-0.380,-0.468,-0.351,P<0.01).Conclusion The decrease phenomenon of peripheral blood EOS exists in the patients with acute urticaria during the onset period.The patients with peripheral blood EOS count decrease have a higher incidence rate of systemic symptoms and more abnormalities of laboratory indicators,in which attention should be paid to.