摘要
In a recent study in Nature,Kadosh et al.1 established a landmark relationship between the gut microbiome and host epigenetics in intestinal oncogenesis.They demonstrated the substantial plasticity of mutant p53 in WNT-driven tumorigenesis,and the crucial involvement of gut microbiome in modulating this plasticity.
基金
supported by National Key R&D Program of China(No.2018YFC1315000/2018YFC1315004)
RGC-CRF Hong Kong(C4039-19G)and RGCGRF Hong Kong(14163817).
