摘要
Nicotinamide adenine dinucleotide phosphate(NADPH)is an essential electron donor in all organisms,and provides the reducing power for anabolic reactions and redox balance.NADPH homeostasis is regulated by varied signaling pathways and several metabolic enzymes that undergo adaptive alteration in cancer cells.The metabolic reprogramming of NADPH renders cancer cells both highly dependent on this metabolic network for antioxidant capacity and more susceptible to oxidative stress.Modulating the unique NADPH homeostasis of cancer cells might be an effective strategy to eliminate these cells.In this review,we summarize the current existing literatures on NADPH homeostasis,including its biological functions,regulatory mechanisms and the corresponding therapeutic interventions in human cancers,providing insights into therapeutic implications of targeting NADPH metabolism and the associated mechanism for cancer therapy.
基金
supported by funding from MEI Pharma,Inc.,the Wayne State Graduate Research Assistantship,the Ring Screw Textron Endowed Chair for Pediatric Cancer Research,Children’s Hospital of Michigan Foundation,Kids Without Cancer,LaFontaine Family/U Can-Cer Vive Foundation,the Decerchio/Guisewite Family,Justin’s Gift,Elana Fund,and the Ginopolis/Karmanos Endowment and supported by the Barbara Ann Karmanos Cancer Institute,Wayne State University School of Medicine.The Animal Model and Therapeutics Evaluation Core is supported,in part,by NIH Center Grant P30 CA022453 to the Karmanos Cancer Institute at Wayne State University.The funders had no role in study design,data collection,analysis and interpretation of data,decision to publish,or preparation of the manuscript.
