摘要
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1(Pin1)controls the functional switch of phosphoproteins and plays an oncogenic role in human cancer,but the discovery of effective Pin1 inhibitors remains challenging.A recent study by Pinch et al.developed a novel Pin1 inhibitor by endowing molecule with covalent reactivity toward Pin1 cysteine-113,1 providing new insights into the design of anticancer Pin1 inhibitors.
基金
supported by National Natural Science Foundation of China(81702980)
Science and Technology Foundation of Sichuan Province,China(2019JDTD0013)
the 1.3.5 Project for Disciplines of Excellence,West China Hospital,Sichuan University(ZYJC18030 and ZYGD20008)
the Postdoctoral Science Foundation of Sichuan University(2019SCU12037).
