摘要
Growing evidences suggest that the fibroblast growth factor/FGF receptor(FGF/FGFR)signaling has crucial roles in a multitude of processes during embryonic development and adult homeostasis by regulating cellular lineage commitment,differentiation,proliferation,and apoptosis of various types of cells.In this review,we provide a comprehensive overview of the current understanding of FGF signaling and its roles in organ development,injury repair,and the pathophysiology of spectrum of diseases,which is a consequence of FGF signaling dysregulation,including cancers and chronic kidney disease(CKD).In this context,the agonists and antagonists for FGF-FGFRs might have therapeutic benefits in multiple systems.
基金
The National Key Research and Development Program of China(2018YFA0800802)
National Natural Science Foundation of China(81530071,81772306,81721001,81991513)
Innovative Research Team in University(IRT1216)
Key research and development projects of science and technology innovation of social undertakings and people’s livelihood security in Chongqing(cstc2017shms-zdyfX0027).
