Achyranthes bidentata polysaccharide can safely prevent NSCLC metastasis via targeting EGFR and EMT

Dear Editor,Cancer metastasis,dissemination of cancer cells from primary tumors to distant sites,attributes to 90%cancer-related death.1 Although the targeted therapies,bio-nanomaterial-based target delivery,and the consequent adoption of the so-called personalized medicine have obtained notable achievements in some cancers,significant problems still exist with these approaches.2 There are hardly any cancer therapeutic agents that can interfere with metastasized cancer.In recent times,we proposed a novel concept,namely cancer metastasis chemoprevention,which is different from the existing cancer chemotherapy and cancer chemoprevention.Cancer metastasis chemoprevention aims at safely preventing circulating tumor cells(CTCs)and related molecules from gemmating into the metastatic tissues.The strategy does not intend to kill cancer cells as cancer chemotherapy does,nor to aimlessly prevent cancers from carcinogenesis as cancer chemoprevention does.