摘要
Dear Editor,Colorectal cancer(CRC)is one of the most frequent diseases with high mortality around the world.Conventional treatments of CRC remain unsatisfactory due to the increasing recurrence rate and adverse reactions including neutropenia,drug resistance,etc.Recently,autophagy has been shown to be involved in regulating cancer development and progression by regulating apoptosis through pro-apoptosis proteins including caspases,in addition to being a potential target for cancer therapeutic intervention.1 Trifolirhizin(Supplementary Fig.S1a)is a natural flavonoid glycosides isolated from Sophora flavescens as well as a bioactive constituent of Xian-Lian-Ke-Li,a commercial traditional Chinese medicine for the cancer prevention.Numerous evidence manifested that trifolirhizin inhibited proliferative activity in melanoma B16 cell,lung cancer H23 cell,human ovarian A2780 cell,and human gastric cancer cell MKN45.2 However,its pharmacological effect and mechanism on CRC remain elusive.Herein,we evaluated the effect of trifolirhizin on autophagy and apoptosis on CRC as well as its related mechanisms,in order to provide evidence to develop a potential agent with less adverse effect in treating CRC.
基金
supported by the National Natural Science Foundation of China(81930117,81673559,81973523)
National Key Research and Development Project(2017YFC1700602)
funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions.
