期刊文献+

The role of histone methylation in the development of digestive cancers:a potential direction for cancer management 被引量:6

原文传递
导出
摘要 Digestive cancers are the leading cause of cancer-related death worldwide and have high risks of morbidity and mortality.Histone methylation,which is mediated mainly by lysine methyltransferases,lysine demethylases,and protein arginine methyltransferases,has emerged as an essential mechanism regulating pathological processes in digestive cancers.Under certain conditions,aberrant expression of these modifiers leads to abnormal histone methylation or demethylation in the corresponding cancer-related genes,which contributes to different processes and phenotypes,such as carcinogenesis,proliferation,metabolic reprogramming,epithelial–mesenchymal transition,invasion,and migration,during digestive cancer development.In this review,we focus on the association between histone methylation regulation and the development of digestive cancers,including gastric cancer,liver cancer,pancreatic cancer,and colorectal cancer,as well as on its clinical application prospects,aiming to provide a new perspective on the management of digestive cancers.
出处 《Signal Transduction and Targeted Therapy》 SCIE CSCD 2020年第1期1226-1238,共13页 信号转导与靶向治疗(英文)
基金 supported by the National Nature Science Foundation of China(2019,81972321 to L.Y. 2019,81974376 to Y.P.Z.).
  • 相关文献

参考文献4

二级参考文献2

共引文献180

同被引文献31

引证文献6

二级引证文献9

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部