摘要
Dear Editor,As an emerging drug discovery paradigm,Proteolysis targeting chimeras(PROTACs)facilitate ubiquitination and degradation of the targets by cellular endogenous proteasome system.Compared with traditional small molecular inhibitors,PROTACs work like enzymes and can operate with or without functional inhibition of the targets,which endows this strategy to degrade drug targets,especially useful for“undruggable”ones.
基金
supported in part by National Natural Science Foundation of China(81673304,81973160,and 81830083)
Innovation Program of Shanghai municipal education commission(2017-01-07-00-05-E00011)
Shenzhen Municipal Government of China(KQTD201708101602260820)
the Fundamental Research Funds for the Central Universities(44300-19311-542500/006)
ECNU Public Platform for Innovation(011).
