摘要
A recent article by Hedge et al.(Cancer Cell 37,289–307.e289,2020)demonstrated that decreased dendritic cell and elevated Th17 cell could explain the immunosuppressive environment of PDAC when compared with that in lung carcinoma.Boosting DC population using Flt3L and CD40 agonist showed improved efficacy on PDAC mouse models and shed new light on its immunotherapeutic strategies.
基金
supported by the Ministry of Science and Technology(2019YFA0801703)
the National Natural Science Foundation of China(81790250,81790253,91959202,81902823)
the Innovation Program of Shanghai Municipal Education Commission(N173606).
