摘要
Immunotherapy,designed to exploit the functions of the host immune system against tumors,has shown considerable potential against several malignancies.However,the utility of immunotherapy is heavily limited due to the low response rate and various side effects in the clinical setting.Immune escape of tumor cells may be a critical reason for such low response rates.Noncoding RNAs(ncRNAs)have been identified as key regulatory factors in tumors and the immune system.Consequently,ncRNAs show promise as targets to improve the efficacy of immunotherapy in tumors.However,the relationship between ncRNAs and tumor immune escape(TIE)has not yet been comprehensively summarized.In this review,we provide a detailed account of the current knowledge on ncRNAs associated with TIE and their potential roles in tumor growth and survival mechanisms.This review bridges the gap between ncRNAs and TIE and broadens our understanding of their relationship,providing new insights and strategies to improve immunotherapy response rates by specifically targeting the ncRNAs involved in TIE.
基金
supported by funding from the Project Nn10 of Harbin Medical University Cancer Hospital(Grant Number Nn102017-02)
National Natural Science Foundation of China(Grant Number 81602323,81872149)
Outstanding Youth Project of Heilongjiang Provincial Natural Science Foundation(Grant Number YQ2019H027)
Distinguished Young Scholars of Harbin Medical University Cancer Hospital(Grant Number JCQN2018-03)
Yong Elite Training Foundation Grant of Harbin Medical University Cancer Hospital(Grant Number JY2016-02)
Haiyan Fund Project of Harbin Medical University Cancer Hospital(Grant Number JJQN 2018-10).
