摘要
Dear Editor,Human immunodeficiency virus type 1(HIV-1)infection is mainly initiated on mucosal epithelial surfaces.Exposure to HIV-1 impairs the mucosal epithelial barrier,allowing viral transmission across the mucosal epithelium.1 Interaction of HIV-1 envelope glycoprotein gp120 with its primary receptor,cluster of differentiation 4(CD4),and chemokine coreceptors has been implicated in the disruption of epithelial cell junctions upon HIV-1 exposure.1 However,the molecular details and underlying mechanisms of this disruption remain elusive.
基金
supported by grants from the National Natural Science Foundation of China(31471262,31701209,and 31771542).
