摘要
Recently,a paper published in Cell by Theodore L.Roth et al.reported the development of a platform to assess the functional effects of pooled knockin constructs targeting a specific locus in the genome.It also provided a strategy that allows discovery of novel synthetic constructs in the pools to enable engineering T cells with gain of function and promote antitumor activity of T cells in vivo.
基金
supported by the Chinese National Natural Science Funds(81902947,82041009,31925013,31671457,91753139,and 31871405)
a special program from the Ministry of Science and Technology of China(2016YFA0502500)
Jiangsu Provincial Distinguished Young Scholars award(BK20180043)
the Key Project of University Natural Science Foundation of Jiangsu Province(19KJA550003)
A project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions.
