摘要
Cytosolic DNA is an indicator of pathogen invasion or DNA damage.The cytosolic DNA sensor cyclic guanosine monophosphateadenosine monophosphate(cGAMP)synthase(cGAS)detects DNA and then mediates downstream immune responses through the molecule stimulator of interferon genes(STING,also known as MITA,MPYS,ERIS and TMEM173).Recent studies focusing on the roles of the cGAS-STING pathway in evolutionary distant species have partly sketched how the mammalian cGAS-STING pathways are shaped and have revealed its evolutionarily conserved mechanism in combating pathogens.Both this pathway and pathogens have developed sophisticated strategies to counteract each other for their survival.Here,we summarise current knowledge on the interactions between the cGAS-STING pathway and pathogens from both evolutionary and mechanistic perspectives.Deeper insight into these interactions might enable us to clarify the pathogenesis of certain infectious diseases and better harness the cGAS-STING pathway for antimicrobial methods.
基金
supported by a special program from Ministry of Science and Technology of China(2016YFA0502500 to L.Z.)
the Chinese National Natural Science Funds(31701232 to F.X.,31900650 to Z.Z.,31671457 and 91753139 to L.Z.
31871405 and 31571460 to F.Z.,31870902 to S.W.)
the National Post-doctoral Program for Innovative Talents(BX201700165 to F.X.,BX20180209 to Z.Z.)
the National Science Foundation for Post-doctoral Scientists of China(2017M62810 to F.X.)
the China Post-doctoral Science Foundation Grant(2018M640522 to Z.Z.)
the Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX18_2524 to T.D).
