急性心梗患者心肌标志物与血清低氧诱导因子-1α的相关性

Relationship between Myocardial Markers and Serum Hypoxia-inducible Factor-1α in Patients with Acute Myocardial Infarction

目的:探讨急性心梗(AMI)患者心肌标志物与血清低氧诱导因子-1α(HIF-1α)的相关性。方法:选取本院在2019年12月-2020年12月确诊并治疗的240例急性胸痛患者,依据临床诊断分为心绞痛组(n=120)及AMI组(n=120)。选取同一时间来本院行健康体检的100名正常健康人群为对照组。检测并比较三组的肌酸激酶(CK)、肌酸激酶同工酶-MB(CK-MB)、肌红蛋白(MYO)、肌钙蛋白(cTnI)、氨基末端脑钠肽前体(NT-proBNP)及HIF-1α水平。分析HIF-1α与CK、CK-MB、MYO、cTnI及NT-proBNP间的相关性。结果:对照组、心绞痛组、AMI组<3 h和3~6 h的MYO、cTnI、NT-proBNP、CK、CK-MB、HIF-1α水平比较,差异均有统计学意义(P<0.05)。AMI组3~6 h的MYO、cTnI、NT-proBNP、CK、CK-MB、HIF-1α水平均高于对照组、心绞痛组、AMI组<3 h,AMI组<3 h的MYO、cTnI、NT-proBNP、CK、CK-MB、HIF-1α水平均高于对照组、心绞痛组,心绞痛组的MYO、cTnI、NT-proBNP、CK、CK-MB、HIF-1α水平均高于对照组,差异均有统计学意义(P<0.05)。HIF-1α水平与CK、CK-MB、MYO、cTnI及NT-proBNP水平均呈正相关(P<0.05)。结论:发生AMI后,患者的血清HIF-1α水平显著升高,同时和患者NT-proBNP、cTnI、MYO、CK-MB、CK均呈正相关性,提示可以将检测血清HIF-1α水平作为临床中评估心肌损伤程度的一项参考指标。

Objective:To investigate the correlation between myocardial markers and serum hypoxiainducible factor-1α(HIF-1α)in patients with acute myocardial infarction.Method:A total of 240 patients with acute chest pain diagnosed and treated in our hospital from December 2019 to December 2020 were selected and divided into angina pectoris group(n=120)and AMI group(n=120)according to clinical diagnosis.A total of 100 healthy people who came to our hospital at the same time were selected as the control group.The levels of creatine kinase(CK),creatine kinase isozyme-MB(CK-MB),myoglobin(MYO),cardiac troponin(cTnI),N-terminal pro brain natriuretic peptide(NT-proBNP)and HIF-1α in the samples were measured and compared.The correlation between HIF-1α and CK,CK-MB,MYO,cTnI and NT-proBNP were analyzed.Result:The levels of MYO,cTnI,NT-proBNP,CK,CK-MB and HIF-1αin control group,angina pectoris group and AMI group<3 h and 3-6 h were compared,the differences were statistically significant(P<0.05).The levels of MYO,cTnI,NT-proBNP,CK,CK-MB and HIF-1αin AMI group at 3-6 h were higher than those in control group,angina pectoris group and AMI group<3 h,the levels of MYO,cTnI,NT-proBNP,CK,CK-MB and HIF-1αin AMI group<3 h were higher than those in control group and angina pectoris group,the levels of MYO,cTnI,NT-proBNP,CK,CK-MB and HIF-1α in angina pectoris group were higher than those in control group,the differences were statistically significant(P<0.05).HIF-1αwas positively correlated with CK,CK-MB,MYO,cTnI and NT-proBNP(P<0.05).Conclusion:After the occurrence of AMI,the serum HIF-1αlevel of patients increased significantly,and is positively correlated with NT-proBNP,cTnI,MYO,CK-MB,CK,suggesting that the detection of serum HIF-1α level could be used as a reference index to evaluate the degree of myocardial injury in clinical practice.