摘要
The main cause of cervical cancer is persistent infection with high-risk human papilloma virus(HR-HPV),but not all human papilloma virus(HPV)infections lead to cervical cancer.The key factors that determine the outcome of HPV infection remain poorly understood,and how the host immune system protects against HPV infection is unclear.Toll-like receptors(TLRs)are a group of pattern recognition receptors present in the cytoplasm and cell membrane,and can specifically recognize pathogen-associated molecular patterns.As the key molecules of innate and acquired immunity,TLRs not only play important roles in the immune defense against infectious diseases,but also are involved in the occurrence and development of a variety of malignant tumors.In cervical cancer caused by HR-HPV infection,TLRs have been found to regulate the local immune microenvironment.The role of TLRs in HR-HPV infection and HPV-induced cervical cancer and its relationship with HPV vaccine are reviewed in this article.
基金
This work is supported by Sandy Rollman Ovarian Cancer Foundation,University of Pennsylvania BCPG Program,University of Pennsylvania URF pilot grant,National Natural Science Foundation of China(81302273)
Health and family Planning Commission of Hubei Province,China(WJ2015MB084),Health Department of Hubei Province,China(2012ZY02)
Science and Technology Department Support Project of Hubei Province,China(2015BCA313).
