摘要
We introduce a single channel neuro-stimulator consisting of a reflector-coupled microscale light emitting diode(μLED)with an integrated mm-sized wireless receiver(Rx)coil for free-floating,battery-free,untethered optogenetics neuromodulation.The system utilizes a two-coil inductive link to deliver instantaneous power at a low operating frequency(<100 MHz)for continuous optical stimulation with minimized invasiveness and tissue exposure to electromagnetic radiation.Coupling a microscale reflector to theμLED provides significant light intensity enhancement compared to a bareμLED.Our activated stimulators have an operational temperature increase of<1℃,well below the safety limit of biomedical implants.In vivo experiment and histological analysis verify the efficacy of wireless optical stimulation in the primary visual cortex of rats,using c-Fos biomarker as a reporter of light-evoked neuronal activity.
基金
This work was supported in part by the National Science Foundation under ECCS-1407880 and Michigan State University。
