前列地尔联合奥拉西坦治疗动脉粥样硬化性脑梗死患者的临床效果

Clinical Effect of Alprostadil Combined with Oxiracetam in the Treatment of Patients with Atherosclerotic Cerebral Infarction

目的:探讨前列地尔联合奥拉西坦对动脉粥样硬化性脑梗死患者临床疗效及对血脂水平、血液流变学指标、神经功能及脑血灌注量的影响。方法:选取2017年6月-2020年6月于本院住院的动脉粥样硬化性脑梗死患者104例,将其随机分为对照组与病例组,每组52例。对照组采用奥拉西坦治疗,病例组采用奥拉西坦联合前列地尔。比较两组临床疗效、治疗前后颈动脉超声检测指标、血脂水平、血液流变学指标、神经功能评估指标以及脑血流灌注指标。结果:病例组治疗总有效率为94.23%高于对照组的80.77%,差异有统计学意义(P<0.05)。治疗后,两组颈动脉管腔面积(LA)、斑块面积(PA)、内膜中层厚度(IMT)和Crouse积分、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL)、全血低切黏度、全血高切黏度、血细胞比容、血浆黏度、美国国立卫生院神经功能缺损评分量表(NIHSS)评分、脑卒中神经功能缺损程度评分量表(NFDS)评分、脑血流平均通过时间(MTT)水平均低于治疗前,高密度脂蛋白(HDL)、Barthel指数评分、脑血流量(CBF)水平均高于治疗前,且病例组上述指标均优于对照组(P<0.05)。结论:前列地尔联合奥拉西坦对动脉粥样硬化性脑梗死患者临床疗效显著,可明显改善血脂水平和血液流变学指标,有效促进脑神经功能和血流灌注量的恢复、改善动脉粥样硬化。

Objective:To investigate the clinical efficacy of Alprostadil combined with Oxiracetam in patients with atherosclerotic cerebral infarction and the effects on blood lipid levels,hemorheological indexes,neurological function and cerebral blood perfusion.Method:A total of 104 patients with atherosclerotic cerebral infarction hospitalized in our hospital from June 2017 to June 2020 were selected.They were randomly divided into control group and case group,with 52 patients in each group.The control group was treated with Oxiracetam,while the case group was treated with Oxiracetam combined with Alprostadil.Clinical efficacy,carotid artery ultrasonic detection indexes,blood lipid levels,hemorheology indexes,neurological function evaluation indexes and cerebral blood perfusion indexes before and after treatment were compared between the two groups.Result:The total effective rate in the case group was 94.23% higher than 80.77% in the control group,the difference was statistically significant(P<0.05).After treatment,carotid lumen area(LA),plaque area(PA),intima medial thickness(IMT)and Crouse score,total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL),whole blood low cut viscosity,HCT,plasma viscosity,national institute of health stroke scale(NIHSS)score,neurological functional deficit scale(NFDS)score and cerebral blood flow mean transit time(MTT)were lower than those before treatment,while high density lipoprotein(HDL),Barthel index score and cerebral blood flow(CBF)were higher than those before treatment,and the above indexes in case group were better than those in control group(P<0.05).Conclusion:Alprostadil combined with Oxiracetam has significant clinical efficacy in patients with atherosclerotic cerebral infarction,which can significantly improve the level of blood lipid and hemorheology indexes,effectively promote the recovery of cerebral nerve function and blood perfusion,and improve atherosclerosis.